Description

2-Chloro-1-[4-(2-Chloroacetyl)Piperazin-1-Yl]Ethanone is a versatile and highly reactive bifunctional piperazine derivative, serving as a critical building block in advanced organic synthesis. Its dual reactive chloroacetyl groups make it an indispensable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce piperazine-linked functionalities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, antimicrobial agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the piperazine moiety enhances biological activity.
• Ligand and Catalyst Development: Serves as a scaffold for creating complex chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a cross-linking agent or monomer for producing specialty polymers with tailored thermal and mechanical properties.
• Bioconjugation and Probe Synthesis: Utilized in medicinal chemistry for attaching fluorescent tags or other reporter groups to bioactive molecules.
• Chemical Research: Fundamental building block in academic and industrial R&D for exploring new heterocyclic compounds and reaction methodologies.

Basic Information

Product Name	2-Chloro-1-[4-(2-Chloroacetyl)Piperazin-1-Yl]Ethanone
CAS No.	1703-23-7
Molecular Formula	C8H10Cl2N2O2
Molecular Weight	237.08 g/mol
Synonyms	1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone); Bis(2-chloroacetyl)piperazine; 1,4-Bis(2-chloroacetyl)piperazine; N,N'-Bis(chloroacetyl)piperazine; Piperazine, 1,4-bis(2-chloroacetyl)-; 2,2'-Dichloro-1,1'-piperazinediylethanone
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-[4-(2-Chloroacetyl)Piperazin-1-Yl]Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its reactive nature, store separately from strong bases, oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.