Description

4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring a halogen, methoxy, and trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Serves as a core structure for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Used in the research of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient quinoline core.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in transition metal catalysis for asymmetric synthesis.
• Fluorine Chemistry Building Block: The presence of the trifluoromethyl group makes it valuable for introducing fluorine atoms into target molecules to modulate lipophilicity, metabolic stability, and bioavailability.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline
CAS No.	1701-27-5
Molecular Formula	C₁₁H₇ClF₃NO
Molecular Weight	261.63 g/mol
Synonyms	4-Chloro-6-methoxy-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-4-chloro-6-methoxyquinoline; 6-Methoxy-4-chloro-2-trifluoromethylquinoline; Quinoline, 4-chloro-6-methoxy-2-(trifluoromethyl)-; 1701-27-5; 4-Chloro-6-methoxy-2-trifluoromethylquinoline; 4-Chloro-6-methoxy-2-(trifluoromethyl)chinolin (German)
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.