Description

N6-Carbobenzoxy-L-Lysine n-Carboxyanhydride is a specialized amino acid derivative and a key protected building block in peptide synthesis. Its primary value lies in enabling the controlled, sequential addition of lysine residues while protecting the side-chain amine group, which is critical for producing peptides with high purity and defined sequences. This compound is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science, where precise molecular construction is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected lysine NCA for the efficient, racemization-free incorporation of lysine into peptide chains.
• Solution-Phase Peptide Synthesis: For the synthesis of specific peptide fragments and small oligopeptides in solution.
• Bioconjugation and Linker Chemistry: Serves as a precursor for creating functionalized peptides with reactive handles for attaching drugs, labels, or polymers.
• Research & Development of Bioactive Peptides: Used in academic and industrial R&D to create novel peptide-based therapeutics, hormones, and enzyme inhibitors.
• Poly(amino acid) and Biomaterial Synthesis: Employed in the ring-opening polymerization to create polylysine-based carriers, coatings, and scaffolds for biomedical applications.
• Production of Custom Peptide Libraries: A critical reagent for combinatorial chemistry approaches to screen for new biological activities.

Basic Information

Product Name	N6-Carbobenzoxy-L-Lysine n-Carboxyanhydride
CAS No.	1676-86-4
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	Nε-Cbz-L-lysine NCA; Z-L-Lysine NCA; N6-Carbobenzoxy-L-lysine N-carboxyanhydride; (S)-2,5-Dioxo-4-(5-((((benzyloxy)carbonyl)amino)pentyl)oxazolidine-3-carboxylic acid; Cbz-L-Lys NCA; NCA of Z-L-Lysine; Nε-Z-L-Lysine NCA; Nα-Carboxy-Nε-carbobenzoxy-L-lysine anhydride
EINECS	Contact for details

Quality Control

Our N6-Carbobenzoxy-L-Lysine n-Carboxyanhydride is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, THF; slightly soluble in ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.