Description

γ-Benzyl L-Glutamate is a protected amino acid derivative of L-glutamic acid, where the γ-carboxyl group is esterified with benzyl alcohol. This compound is a critical chiral building block and intermediate in organic synthesis and peptide chemistry, valued for its role in introducing the glutamic acid moiety under controlled conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing peptides, prodrugs, and other bioactive molecules.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of peptides containing glutamic acid residues.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation & Linker Chemistry: Used in the preparation of conjugates for drug delivery systems and biochemical probes, where the benzyl ester can be selectively cleaved.
• Polymer Science: Acts as a monomer for the synthesis of poly(amino acid)s and biodegradable polymers with specific functional properties.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor analog in metabolic pathway research.
• Fine Chemical Synthesis: Utilized as a chiral synthon for the asymmetric synthesis of complex organic molecules and natural product analogs.

Basic Information

Product Name	γ-Benzyl L-Glutamate
CAS No.	1676-73-9
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	L-Glutamic acid 5-benzyl ester; (S)-2-Amino-5-(benzyloxy)-5-oxopentanoic acid; H-Glu(OBzl)-OH; N-Bzl-L-glutamic acid; Benzyl L-glutamate; γ-Benzyl L-glutamate; GLU(OBZL); Bzl-Glu-OH
EINECS	216-824-5

Quality Control

Our γ-Benzyl L-Glutamate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for research and synthesis applications. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-17.0° to -19.0° (c=1 in AcOH)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.