Description

n-Tfa-L-Tryptophan Methyl Ester is a protected derivative of the essential amino acid L-tryptophan, where the amine group is shielded by a trifluoroacetyl (Tfa) group and the carboxylic acid is esterified. This compound matters as a crucial chiral building block and intermediate in the synthesis of complex peptides, pharmaceuticals, and bioactive molecules, offering precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of peptide-based drugs, protease inhibitors, and other therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry as a protected tryptophan residue to prevent side reactions during coupling.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction research.
• Fine Chemical Production: Intermediate in the manufacture of specialized agrochemicals, flavors, and fragrances requiring high-purity chiral precursors.
• Protecting Group Chemistry: Demonstrates the application of the acid-labile trifluoroacetyl group for temporary amine protection in multi-step syntheses.

Basic Information

Product Name	n-Tfa-L-Tryptophan Methyl Ester
CAS No.	1604-49-5
Molecular Formula	C₁₅H₁₅F₃N₂O₃
Molecular Weight	328.29 g/mol
Synonyms	N-(Trifluoroacetyl)-L-tryptophan methyl ester; L-Tryptophan, N-[(trifluoroacetyl)]-, methyl ester; Methyl N-trifluoroacetyl-L-tryptophanate; TFA-L-Trp-OMe; N-α-Trifluoroacetyl-L-tryptophan methyl ester; (S)-Methyl 2-(2-((trifluoroacetyl)amino)-3-(1H-indol-3-yl)propanoate; Trifluoroacetyltryptophan methyl ester
EINECS	Contact for details

Quality Control

Our n-Tfa-L-Tryptophan Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.