Description

trans-3-Phenylcyclobutan-1-Amine is a versatile chiral amine building block featuring a cyclobutane ring system. This compound is valued for its rigid, three-dimensional structure, which is crucial for modulating the biological activity and physicochemical properties of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in creating novel herbicides and pesticides where the cyclobutane scaffold can enhance stability and target specificity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique structural properties.
• Chemical Biology Probes: Useful for constructing molecular probes to study biological pathways and protein interactions.

Basic Information

Product Name	trans-3-Phenylcyclobutan-1-Amine
CAS No.	1570-99-6
Molecular Formula	C10H13N
Molecular Weight	147.22 g/mol
Synonyms	(1R,3S)-3-Phenylcyclobutanamine; (1S,3R)-3-Phenylcyclobutanamine; trans-3-Phenylcyclobutanamine; 3-Phenylcyclobutan-1-amine; (±)-trans-3-Phenylcyclobutan-1-amine; rac-trans-3-Phenylcyclobutan-1-amine; 1-Amino-3-phenylcyclobutane
EINECS	Contact for details

Quality Control

Our trans-3-Phenylcyclobutan-1-Amine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.