Description

H-p-Fluoro-Phe-Oet Hcl is a high-purity, non-natural amino acid derivative specifically designed for advanced chemical synthesis. This compound is a critical chiral building block, offering a para-fluorinated phenylalanine side chain protected as an ethyl ester hydrochloride salt, which is essential for introducing specific fluorinated motifs into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive compounds where fluorine substitution is used to modulate metabolic stability, lipophilicity, and receptor binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate fluorinated phenylalanine residues, enhancing the biological and physicochemical properties of synthetic peptides.
• Chemical Biology & Proteomics: Serves as a building block for creating fluorinated probes, inhibitors, and substrates to study enzyme mechanisms and protein-protein interactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the effects of fluorine substitution on potency, selectivity, and pharmacokinetic profiles of drug candidates.
• Agrochemical Development: Potential use as an intermediate in the synthesis of advanced, fluorinated agrochemicals with improved efficacy and environmental profiles.

Basic Information

Product Name	H-p-Fluoro-Phe-Oet Hcl
CAS No.	1534-90-3
Molecular Formula	C11H14FNO2·HCl
Molecular Weight	247.69 g/mol (Free base: 211.23 g/mol)
Synonyms	H-Phe(4-F)-OEt·HCl; (S)-2-Amino-3-(4-fluorophenyl)propanoic acid ethyl ester hydrochloride; Ethyl L-4-fluorophenylalaninate hydrochloride; L-4-Fluorophenylalanine ethyl ester hydrochloride; Fmoc-Phe(4-F)-OH precursor; p-Fluoro-L-phenylalanine ethyl ester HCl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-L-phenylalanine ethyl ester (deprotected form); 4-F-Phe-OEt·HCl
EINECS	Contact for details

Quality Control

Our H-p-Fluoro-Phe-Oet Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to industry-standard analytical protocols to support your critical synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.