Description

cis-Cyclobutane-1,2-Dicarboxylic Acid is a high-purity, strained-ring dicarboxylic acid building block of significant interest in advanced organic synthesis and pharmaceutical research. Its unique cis-fused cyclobutane structure provides a rigid, three-dimensional scaffold that is valuable for modulating the conformational and physicochemical properties of target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as medicinal chemistry, ligand design, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring constrained geometries.
• Medicinal Chemistry & Drug Discovery: Used to introduce the strained cyclobutane motif into lead compounds to improve potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides, fungicides, and insecticides with unique modes of action.
• Ligand and Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polyesters and polyamides with enhanced thermal and mechanical properties.
• Academic & Industrial Research: A valuable reagent for studying ring-strain reactions and developing new synthetic methodologies.

Basic Information

Product Name	cis-Cyclobutane-1,2-Dicarboxylic Acid
CAS No.	1461-94-5
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	(1R,2S)-Cyclobutane-1,2-dicarboxylic Acid; (1S,2R)-Cyclobutane-1,2-dicarboxylic Acid; cis-1,2-Cyclobutanedicarboxylic Acid; rel-(1R,2S)-Cyclobutane-1,2-dicarboxylic Acid; Cyclobutane-1,2-dicarboxylic Acid, cis-; 1,2-Cyclobutanedicarboxylic Acid, (1R,2S)-rel-; NSC 163044
EINECS	Contact for details

Quality Control

Our cis-Cyclobutane-1,2-Dicarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.