Description

Nisin CAS NO 1414-45-5 is a natural, polycyclic antibacterial peptide produced by certain strains of *Lactococcus lactis*. This compound is highly valued for its potent antimicrobial activity against a broad spectrum of Gram-positive bacteria, including foodborne pathogens and spoilage organisms. It is an essential ingredient for manufacturers in the global food and beverage, pharmaceutical, and personal care industries seeking effective, label-friendly preservation solutions.

Application

• Food Preservation: Widely used as a natural preservative (E234) in dairy products (cheese, yogurt, clotted cream), canned foods, processed meats, and beverages to inhibit spoilage bacteria like *Listeria* and *Clostridium botulinum*.
• Pharmaceutical Formulations: Employed as a preservative in topical creams, ointments, and certain oral dosage forms to prevent microbial contamination without compromising product stability.
• Animal Feed Additive: Incorporated into feed to promote gut health and improve feed efficiency in livestock by controlling pathogenic bacteria.
• Dental Care Products: Used in mouthwashes, toothpastes, and chewing gums for its anti-plaque and anti-caries properties against oral streptococci.
• Biotechnology Research: Serves as a selective agent in microbiological media and as a model lantibiotic in biochemical and genetic studies.
• Personal Care & Cosmetics: Acts as a natural preservative in creams, lotions, and deodorants to extend shelf-life and enhance product safety.

Basic Information

Product Name	Nisin
CAS No.	1414-45-5
Molecular Formula	C143H230N42O37S7
Molecular Weight	3354.07 g/mol
Synonyms	Nisin A; Nisin Z; E 234; INS 234; Nisin preparation; Lantibiotic Nisin; Nisin peptide; Antibiotic Nisin; Nisaplin®; Chrisin®
EINECS	215-807-5

Quality Control

Our Nisin is manufactured and tested to meet stringent quality standards, including Food Chemicals Codex (FCC) and relevant food safety regulations (GRAS status in the US, approved under E234 in the EU). Every batch undergoes comprehensive analysis for potency, purity, and microbiological safety. A Certificate of Analysis (COA) detailing assay results, microbiological limits, and physical specifications is provided to ensure full traceability and compliance for your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect potency.

Specification

Item	Specification
Appearance	White to light tan powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 900 IU/mg (or as specified)
pH (10% suspension)	3.0 - 5.0
Loss on Drying	≤ 3.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals (as Pb)	≤ 10 ppm
Total Plate Count	≤ 1000 CFU/g
Yeast & Mold	≤ 100 CFU/g
E. coli	Negative
Salmonella	Negative

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.