Description

Thioflavine S is a synthetic, cationic benzothiazole dye widely recognized for its strong affinity to amyloid fibrils and other protein aggregates. This property makes it an indispensable tool in biomedical research and diagnostic applications, particularly for staining and detecting pathological protein structures. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and life sciences sectors for applications ranging from basic histology to advanced drug discovery.

Application

• Amyloid Plaque Staining: A primary histological stain for visualizing amyloid-beta plaques in brain tissue sections, crucial for Alzheimer's disease research.
• Protein Aggregation Studies: Used in vitro to monitor the kinetics of fibril formation and to screen for compounds that inhibit or disrupt amyloid aggregation.
• Textile Dyeing: Functions as a specialized dye for silk, wool, and nylon, providing yellow to greenish-yellow shades.
• Biological Fluorescence Microscopy: Employed as a fluorescent marker due to its enhanced fluorescence upon binding to amyloid structures, enabling detailed imaging.
• Paper and Leather Coloring: Used as a colorant in specific paper and leather finishing processes.
• Diagnostic Reagent Component: Incorporated into staining kits and reagents for clinical pathology and laboratory diagnostics.

Basic Information

Product Name	Thioflavine S
CAS No.	1326-12-1
Molecular Formula	C26H21N2NaO6S3
Molecular Weight	580.63 g/mol
Synonyms	Acid Yellow 36; C.I. 49005; Thioflavin S; Direct Yellow 7; Benzothiazolium, 2-[2-[4-(dimethylamino)phenyl]ethenyl]-6-methyl-, methyl sulfate; CI 49005; Cotton Yellow 7G; Thiazol Yellow G
EINECS	215-393-3

Quality Control

Every batch of Thioflavine S is subjected to rigorous analytical testing to ensure identity, purity, and performance consistency suitable for research and industrial use. Our quality assurance protocol includes spectroscopic analysis and chromatographic methods. A comprehensive Certificate of Analysis (COA) detailing purity, absorbance characteristics, and other critical parameters is provided with each shipment to support your quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to Brownish-Yellow Powder
Identification (IR)	Conforms to Standard
Assay (HPLC)	≥ 85% (Dye Content)
Loss on Drying	≤ 5.0 %
Absorbance (λmax)	Contact for details
Fluorescence Properties	Contact for details
Solubility	Soluble in Water, Slightly soluble in Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.