Description

Nalpha-Cbz-L-Arginine is a protected derivative of the essential amino acid L-arginine, where the α-amino group is blocked with a carboxybenzyl (Cbz) protecting group. This modification is critical for its primary role as a key building block in the solid-phase synthesis of peptides and peptidomimetics, ensuring precise control over the peptide chain assembly. It is an indispensable raw material for research institutions, pharmaceutical developers, and fine chemical manufacturers focused on creating bioactive peptides, therapeutic agents, and novel drug candidates.

Application

• Peptide Synthesis: A fundamental reagent in Fmoc/t-Bu and Boc/Bzl solid-phase peptide synthesis (SPPS) protocols.
• Pharmaceutical Intermediates: Serves as a critical precursor in the production of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, signal transduction, and protein function.
• Proteomics & Diagnostics: Employed in the synthesis of labeled peptides and antigens for diagnostic assay development and biomarker discovery.
• Cosmeceutical Actives: A component in the synthesis of specialized peptides for advanced skincare and anti-aging formulations.

Basic Information

Product Name	Nalpha-Cbz-L-Arginine
CAS No.	1234-35-1
Molecular Formula	C14H20N4O4
Molecular Weight	308.33 g/mol
Synonyms	Nα-Carbobenzoxy-L-arginine; Z-L-Arginine; Nα-Cbz-L-Arginine; CBZ-L-Arginine; Nα-(Benzyloxycarbonyl)-L-arginine; L-Arginine, N2-[(phenylmethoxy)carbonyl]-; (S)-2-((((Benzyloxy)carbonyl)amino)-5-guanidinopentanoic acid; Arg(Z)-OH
EINECS	Contact for details

Quality Control

Our Nalpha-Cbz-L-Arginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+10.5° to +12.5° (c=1 in AcOH)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.