Description

(4-Amino-Cyclohexyl)-Acetic Acid CAS NO 1197-54-2 is a versatile amino acid derivative featuring a cyclohexyl backbone, offering a unique combination of structural rigidity and functional group reactivity. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular design is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and peptide mimetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and plant growth regulators, leveraging its structural properties for enhanced bioactivity.
• Peptidomimetics & Drug Discovery: Serves as a constrained scaffold in medicinal chemistry for creating novel peptide analogs and probing structure-activity relationships (SAR).
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Specialty Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce amino functionality into polymers for specialized coatings and materials.
• Bioconjugation & Linker Chemistry: Utilized in the design of cleavable linkers for antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	(4-Amino-Cyclohexyl)-Acetic Acid
CAS No.	1197-54-2
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	4-Aminocyclohexaneacetic Acid; trans-4-Aminocyclohexylacetic Acid; cis-4-Aminocyclohexylacetic Acid; 2-(4-Aminocyclohexyl)acetic Acid; 4-Amino-1-cyclohexaneacetic Acid; (4-Aminocyclohexyl)ethanoic Acid; Cyclohexaneacetic acid, 4-amino-
EINECS	214-819-6

Quality Control

Our (4-Amino-Cyclohexyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (trans/cis ratio available)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.