Description

n-Carbobenzyloxy-L-Valine CAS NO 1149-26-4 is a protected amino acid derivative, specifically the carbobenzyloxy (Cbz) derivative of L-valine. This compound serves as a critical building block in the synthesis of peptides and other complex organic molecules, offering a versatile and stable protecting group for the amine functionality. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, sequential addition of amino acids, particularly valine, in automated peptide synthesis.
• Solution-Phase Peptide Synthesis: Used in traditional coupling reactions for the production of custom peptides and peptide fragments.
• Pharmaceutical Intermediate: A key starting material or intermediate in the multi-step synthesis of peptide-based drugs and therapeutic compounds.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides and proteins for research, diagnostics, and targeted drug delivery systems.
• Organic Synthesis Building Block: Employed in the preparation of non-peptidic compounds where the valine moiety or a protected amine is required.
• Academic and R&D Laboratories: Essential for fundamental research in medicinal chemistry, biochemistry, and chemical biology.

Basic Information

Product Name	n-Carbobenzyloxy-L-Valine
CAS No.	1149-26-4
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	N-Cbz-L-Valine; N-Carbobenzyloxy-L-valine; N-(Benzyloxycarbonyl)-L-valine; Z-L-Valine; Z-Val-OH; L-Valine, N-[(phenylmethoxy)carbonyl]-; Benzyl N-L-valylcarbamate; (S)-2-((Benzyloxycarbonyl)amino)-3-methylbutanoic acid
EINECS	214-560-5

Quality Control

Our n-Carbobenzyloxy-L-Valine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, correct stereochemistry, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), optical rotation, and impurity profiles. Our quality commitment supports applications requiring GMP-grade or research-grade materials, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Optical Rotation	-3.0° to -5.0° (c=1 in Acetic Acid)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.