Description

3-Oxobutyric Acid Menthyl Ester is a high-purity organic ester compound, valued for its unique combination of a ketone functional group and a chiral menthyl moiety. This structure makes it a versatile intermediate and chiral building block in advanced organic synthesis. It is primarily sought after by the pharmaceutical, fragrance, and specialty chemical industries for applications requiring specific stereochemistry and functional group compatibility.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring the menthyl group as a chiral auxiliary or for introducing specific ketone functionalities.
• Fragrance and Flavor Ingredient: Used in the development of complex aroma chemicals, leveraging the characteristic minty/woody notes of the menthyl group for sophisticated fragrance compositions.
• Organic Synthesis Reagent: Acts as a protected form of acetoacetic acid or as a starting material for Claisen condensation and other C-C bond-forming reactions in fine chemical production.
• Asymmetric Catalysis Research: Employed in academic and industrial R&D as a standard substrate or ligand precursor for developing and testing new chiral catalysts and methodologies.
• Specialty Polymer Modifier: Utilized to introduce chiral centers or ketone functionalities into polymer chains for creating materials with specialized optical or chemical properties.

Basic Information

Product Name	3-Oxobutyric Acid Menthyl Ester
CAS No.	1144-50-9
Molecular Formula	C14H24O3
Molecular Weight	240.34 g/mol
Synonyms	Menthyl Acetoacetate; (-)-Menthyl Acetoacetate; L-Menthyl Acetoacetate; Acetoacetic Acid Menthyl Ester; 3-Oxobutanoic Acid, (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; Acetoacetic Acid (-)-Menthyl Ester; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 3-oxobutanoate
EINECS	214-537-9

Quality Control

Our 3-Oxobutyric Acid Menthyl Ester is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (L-Menthyl)
Specific Rotation	-70° to -80° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.