Description

Cyclododecyne is a strained, cyclic alkyne with a 12-membered carbon ring, a key building block in advanced organic synthesis. Its unique structure, featuring a triple bond within a medium-sized ring, makes it a valuable precursor for creating complex macrocyclic and cage-like molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the construction of complex macrocyclic drug candidates, particularly for targeting challenging biological receptors.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with unique modes of action derived from strained-ring systems.
• Materials Science Research: Acts as a monomer or cross-linking agent in the development of novel polymers with tailored mechanical or optical properties.
• Click Chemistry: An advanced substrate for strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, useful in bioconjugation and materials labeling without catalysts.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for the synthesis of complex natural product analogs and molecular cages.
• Ligand and Catalyst Development: Used to create novel chelating ligands or metal-organic frameworks (MOFs) with specific cavity sizes and reactivity.

Basic Information

Product Name	Cyclododecyne
CAS No.	1129-90-4
Molecular Formula	C₁₂H₂₀
Molecular Weight	164.29 g/mol
Synonyms	Cyclododec-1-yne; 1-Cyclododecyne; Cyclododecyne, 98+%; Cyclododec-1-yne, 98+%; 1-Cyclododecyne, 98+%; Cyclododecyne (stabilized); Cyclododecyne (contains stabilizer)
EINECS	214-458-5

Quality Control

Our Cyclododecyne is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with global regulatory frameworks, including REACH, and can provide material for evaluation under cGMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.