Description

trans-Cyclobutane-1,2-Dicarboxylic Acid is a high-purity, stereochemically defined dicarboxylic acid building block of significant interest in advanced organic synthesis. Its rigid, strained cyclobutane core and precise spatial arrangement of functional groups make it a valuable scaffold for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand design, and polymer research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where its constrained geometry can influence biological activity and selectivity.
• Ligand and Catalyst Development: Employed as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enhancing enantioselectivity in critical bond-forming reactions.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polyamides, polyesters, and other high-performance polymers with unique thermal and mechanical properties.
• Chemical Research & Development: A versatile reagent for methodological studies in organic chemistry, including ring-opening reactions and strain-release functionalization.
• Academic Research: Utilized in universities and research institutes for studying cyclobutane chemistry, reaction mechanisms, and the development of new synthetic methodologies.

Basic Information

Product Name	trans-Cyclobutane-1,2-Dicarboxylic Acid
CAS No.	1124-13-6
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	(1R,2R)-Cyclobutane-1,2-dicarboxylic Acid; (1S,2S)-Cyclobutane-1,2-dicarboxylic Acid; trans-1,2-Cyclobutanedicarboxylic Acid; rel-(1R,2R)-Cyclobutane-1,2-dicarboxylic Acid; Cyclobutane-1,2-dicarboxylic acid, trans-; 1,2-Cyclobutanedicarboxylic acid, (E)-; (R,R)-1,2-Cyclobutanedicarboxylic acid; (S,S)-1,2-Cyclobutanedicarboxylic acid
EINECS	214-386-6

Quality Control

Our trans-Cyclobutane-1,2-Dicarboxylic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and stereochemical composition are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.