Description

4-Chloromethyl-[1,3]Dioxane is a versatile chlorinated acetal derivative, serving as a crucial bifunctional building block in advanced organic synthesis. Its value lies in its ability to act as both a protected aldehyde equivalent and an alkylating agent, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key synthon for the preparation of various drug candidates, particularly those requiring the introduction of chloromethyl or masked aldehyde functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the dioxane ring system contributes to biological activity.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for the synthesis of specialty resins and functional polymers.
• Organic Synthesis Reagent: Employed in nucleophilic substitution reactions and as a precursor to other valuable intermediates like aldehydes and epoxides.
• Ligand and Catalyst Development: Useful for synthesizing chelating ligands and complex organic frameworks used in catalysis.
• Flavor and Fragrance Industry: Serves as a starting material for the synthesis of certain aroma chemicals with green, earthy notes.

Basic Information

Item	Details
Product Name	4-Chloromethyl-[1,3]Dioxane
CAS No.	1121-62-6
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	4-(Chloromethyl)-1,3-dioxane; 1,3-Dioxane-4-methanol, 4-(chloromethyl)-; Chloromethyl dioxane; 4-Chloromethyl-1,3-dioxolane (common misnomer); α-Chloroacetaldehyde ethylene acetal; 2-Chloro-1,3-dioxan-5-ylmethane
EINECS	214-345-8

Quality Control

Our 4-Chloromethyl-[1,3]Dioxane is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.450 - 1.455
Density (20°C)	1.18 - 1.22 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.