Description

4-Bromobenzocyclobutene is a versatile brominated aromatic building block characterized by its unique strained cyclobutene ring fused to a benzene core. This compound matters as a critical intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling reactions and ring-opening transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides with novel modes of action.
• Ligand & Catalyst Precursor: Serves as a starting material for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in catalysis.
• Material Science Building Block: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored optoelectronic properties.
• Cross-Coupling Reactions: A valuable substrate in Suzuki-Miyaura, Stille, and Negishi couplings to introduce the benzocyclobutene moiety into more complex systems.
• Academic & Industrial Research: Fundamental building block for exploring new synthetic methodologies and reaction pathways involving strained ring systems.

Basic Information

Product Name	4-Bromobenzocyclobutene
CAS No.	1073-39-8
Molecular Formula	C8H7Br
Molecular Weight	183.05 g/mol
Synonyms	1-Bromo-4-bicyclo[4.2.0]octa-1,3,5-trien-7-ene; Benzocyclobutene, 4-bromo-; 4-Bromobicyclo[4.2.0]octa-1,3,5-trien-7-ene; 4-Bromo-1,2-dihydrobenzocyclobutene; 7-Bromobicyclo[4.2.0]octa-1,3,5-triene; 4-Bromo-benzocyclobutene; BCB-Br
EINECS	Contact for details

Quality Control

Our 4-Bromobenzocyclobutene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS for identity confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.