Description

Bis-N,N'-(Trimethylsilyl)-n-Phenylurea CAS NO 1024-58-4 is a specialized organosilicon reagent primarily used as a silylating agent and protecting group in advanced organic synthesis. This compound is valued for its ability to introduce the bulky trimethylsilyl (TMS) group, which can modify reactivity and solubility, and protect sensitive functional groups during multi-step reactions. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) where silylation is required for protection or solubility enhancement.
• Agrochemical Synthesis: Serves as a key reagent in the production of advanced pesticides and herbicides.
• Peptide Chemistry: Employed as a protecting agent for amino groups during solid-phase and solution-phase peptide synthesis.
• Nucleoside & Nucleotide Chemistry: Facilitates the protection of exocyclic amino groups in the synthesis of modified nucleosides and oligonucleotides.
• Material Science Precursor: Acts as a starting material or modifying agent in the development of silicon-containing polymers and advanced coatings.
• Analytical Derivatization: Used to derivative compounds for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.

Basic Information

Product Name	Bis-N,N'-(Trimethylsilyl)-n-Phenylurea
CAS No.	1024-58-4
Molecular Formula	C13H24N2OSi2
Molecular Weight	280.52 g/mol
Synonyms	1,3-Bis(trimethylsilyl)-1-phenylurea; N,N'-Bis(trimethylsilyl)-N-phenylurea; Phenylurea, N,N'-bis(trimethylsilyl)-; Urea, N,N'-bis(trimethylsilyl)-N'-phenyl-; BTPU; BTPU Silylating Agent; TMS-Phenylurea Derivative
EINECS	Contact for details

Quality Control

Our Bis-N,N'-(Trimethylsilyl)-n-Phenylurea is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.