Description

1-Ethoxy-2-(Trimethylsilyl)Ethyne is a versatile organosilicon reagent featuring a protected terminal alkyne functionality. This compound is valued for its role as a key synthetic building block in advanced organic and medicinal chemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing acetylene or heterocyclic structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require alkyne coupling reactions.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers, dendrimers, and functionalized surfaces.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Reagent: Employed in laboratories for the protection and subsequent deprotection of terminal alkynes, enabling complex multi-step syntheses.
• Ligand and Catalyst Development: Used to create novel phosphine or N-heterocyclic carbene (NHC) ligands with alkyne handles for metal coordination.

Basic Information

Product Name	1-Ethoxy-2-(Trimethylsilyl)Ethyne
CAS No.	1000-62-0
Molecular Formula	C7H14OSi
Molecular Weight	142.27 g/mol
Synonyms	(Ethoxyethynyl)trimethylsilane; Trimethyl(ethoxyethynyl)silane; Ethoxy(trimethylsilyl)acetylene; 1-Ethoxy-2-(trimethylsilyl)acetylene; Ethynyltrimethylsilane, ethoxy-; TMS-ethoxyacetylene
EINECS	Contact for details

Quality Control

Our 1-Ethoxy-2-(Trimethylsilyl)Ethyne is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.