Description

1,1'-(Pentamethylene)Bis(1-Methylpyrrolidinium) is a high-purity quaternary ammonium compound, also known as Pentamethonium, primarily valued for its potent neuromuscular blocking activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for studying ganglionic blocking agents. It serves the needs of advanced research laboratories, pharmaceutical manufacturers, and chemical suppliers focused on neuromuscular pharmacology and the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of neuromuscular blocking agents and other specialized therapeutic compounds.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of autonomic ganglia and neuromuscular junctions.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method development in analytical laboratories.
• Life Science Reagent: Employed in in-vitro and ex-vivo research models to investigate cholinergic transmission and ganglionic blockade.
• Chemical Synthesis: Acts as a versatile precursor or catalyst in organic synthesis for creating complex nitrogen-containing molecules.

Basic Information

Product Name	1,1'-(Pentamethylene)Bis(1-Methylpyrrolidinium)
CAS No.	144-44-5
Molecular Formula	C15H32N22+ (typically as a salt, e.g., dibromide)
Molecular Weight	240.43 g/mol (for the free dication)
Synonyms	Pentamethonium; Pentamethonium Bromide; 1,1'-[1,5-Pentanediylbis(1-methylpyrrolidinium)]; 1,1'-Pentamethylenebis(1-methylpyrrolidinium); Bis(1-methylpyrrolidinium) pentane; C5; NSC 25141; Pentamethylene bis(1-methylpyrrolidinium)
EINECS	205-628-5

Quality Control

Our 1,1'-(Pentamethylene)Bis(1-Methylpyrrolidinium) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.