Description

Dl-α-Methylleucine is a non-proteinogenic amino acid derivative characterized by its unique branched-chain structure with an additional methyl group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the creation of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to incorporate non-natural amino acid residues into peptide chains to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in catalytic asymmetric reactions to construct stereogenic centers.
• Biochemical Research: Employed in metabolic pathway studies and as a substrate analog for enzyme inhibition assays.
• Fine Chemical Production: Intermediate in the manufacture of specialized agrochemicals, flavors, and fragrances requiring specific stereoisomers.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Dl-α-Methylleucine
CAS No.	144-24-1
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	DL-α-Methylleucine; (±)-2-Amino-4-methylpentanoic acid; 2-Amino-4-methylvaleric acid; DL-2-Amino-4-methylpentanoic acid; α-Methyl-DL-leucine; 4-Methyl-2-aminopentanoic acid; DL-2-Amino-4-methylvaleric acid; (±)-α-Methylleucine
EINECS	205-620-8

Quality Control

Our Dl-α-Methylleucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (50:50 ratio typical)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.