Description

3-Chloro-1-Iodopropyne (CAS NO 109-71-7) is a highly reactive halogenated alkyne building block, valued for its ability to introduce both chloro and iodo functional groups in a single molecule. This dual functionality makes it a critical intermediate for constructing complex molecular architectures in advanced chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the production of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated alkynyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where its reactive halogen atoms facilitate further derivatization.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers and advanced organic materials.
• Organic Synthesis Building Block: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands and organometallic catalysts used in homogeneous catalysis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	3-Chloro-1-Iodopropyne
CAS No.	109-71-7
Molecular Formula	C3H2ClI
Molecular Weight	200.41 g/mol
Synonyms	1-Chloro-3-iodopropyne; 3-Chloro-1-iodo-1-propyne; 3-Chloro-1-iodoprop-1-yne; 1-Iodo-3-chloropropyne; Propyne, 3-chloro-1-iodo-; Chloroiodopropyne; IC≡CCH2Cl
EINECS	203-700-6

Quality Control

Our 3-Chloro-1-Iodopropyne is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, containers should be kept tightly sealed and opened only under controlled conditions to minimize loss and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.