Description

(1aR,2S,5aS,6S,8S,9aR,11R,11aR)-6,8-Bis(acetyloxy)-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione is a complex diterpenoid derivative with a highly functionalized, polycyclic structure. This compound is of significant interest for its role as a key synthetic intermediate in the development of novel pharmaceutical agents, particularly in the field of oncology and anti-inflammatory drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in advanced organic synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of complex natural product analogs and novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents with potential anticancer or anti-inflammatory properties.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Organic Synthesis: Utilized in advanced synthetic methodologies, including stereoselective transformations and multi-step total synthesis projects.
• Biochemical Research: Investigated for its interaction with specific biological targets and pathways in preclinical studies.

Basic Information

Product Name	(1aR,2S,5aS,6S,8S,9aR,11R,11aR)-6,8-Bis(acetyloxy)-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione
CAS No.	71503-82-7
Molecular Formula	C25H32O8
Molecular Weight	460.52 g/mol
Synonyms	Taxinine M; 13-Dehydroxybaccatin VI; 2α,10β-Diacetoxy-5α,9α,13α-trihydroxy-4(20),11-taxadiene-9-one 13,9-carbonate; 5,20-Epoxy-1,7,10-trihydroxy-9-oxo-11-taxen-13-one 1,7-diacetate 13,9-carbonate; NSC 654074; Taxusin derivative M; 2α,10β-Diacetoxytaxa-4(20),11-diene-5α,9α,13α-triol-9-one 13,9-carbonate
EINECS	Contact for details

Quality Control

Our production of (1aR,2S,5aS,6S,8S,9aR,11R,11aR)-6,8-Bis(acetyloxy)-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.