Description

Cbz-α-Allyl-D-Gly CAS NO 127474-54-8 is a protected amino acid derivative featuring an N-terminal carboxybenzyl (Cbz) group and an α-allyl side chain on a D-configuration glycine backbone. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptide libraries.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the D-α-allylglycine residue, which can be further functionalized.
• Protease Inhibitor Development: A valuable precursor for creating inhibitors targeting specific enzymes like caspases or other proteases.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of peptides.
• Conformationally Restricted Peptide Design: The allyl group provides a handle for cross-metathesis or other modifications to create cyclic or constrained peptides.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in asymmetric catalytic reactions due to its defined stereochemistry.

Basic Information

Product Name	Cbz-α-Allyl-D-Gly
CAS No.	127474-54-8
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-α-allylglycine; (R)-2-(((Benzyloxy)carbonyl)amino)pent-4-enoic acid; Z-D-Aag-OH; Cbz-D-α-allylglycine; N-Carbobenzoxy-D-α-allylglycine; N-Cbz-D-2-amino-4-pentenoic acid; (R)-2-((((Benzyloxy)carbonyl)amino)pent-4-enoic acid; D-2-((((Benzyloxy)carbonyl)amino)-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our Cbz-α-Allyl-D-Gly is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Optical Rotation	Specific range provided on COA
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.