Description

Boc-β-Cyclohexyl-D-Alanine Monohydrate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is a critical chiral building block, valued for its role in introducing the sterically hindered, hydrophobic β-cyclohexylalanine side chain in the D-configuration. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where structural specificity and enantiomeric purity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Peptidomimetic Research: Used to incorporate non-natural, conformationally constrained amino acid residues into peptide backbones to enhance metabolic stability and binding affinity.
• API Development: Serves as a critical raw material in the research and process development for Active Pharmaceutical Ingredients (APIs) with specific chiral requirements.
• Bioconjugation & Labeling: The Boc-protected amine allows for selective deprotection and subsequent conjugation with fluorescent dyes, biomarkers, or other functional molecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new lead compounds with optimized pharmacological properties.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry, medicinal chemistry, and biochemistry for studying structure-activity relationships (SAR).

Basic Information

Product Name	Boc-β-Cyclohexyl-D-Alanine Monohydrate
CAS No.	127095-92-5
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol (Anhydrous basis: 269.35 g/mol)
Synonyms	(2R)-3-Cyclohexyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid monohydrate; D-3-Cyclohexylalanine, N-BOC-, monohydrate; N-(tert-Butoxycarbonyl)-3-cyclohexyl-D-alanine monohydrate; N-Boc-3-cyclohexyl-D-alanine monohydrate; Boc-D-Cha-OH · H2O; tert-Butyloxycarbonyl-D-cyclohexylalanine monohydrate; Boc-β-cyclohexyl-D-Ala-OH · H2O
EINECS	Contact for details

Quality Control

Our Boc-β-Cyclohexyl-D-Alanine Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) documenting identity, purity (Assay), chiral purity, water content, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	5.0% - 7.5% (Theoretical for monohydrate: ~6.3%)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.