Description

(R)-2-Phenyl-3-Methylbutanoic Acid CAS NO 13491-13-9 is a high-purity chiral building block of significant importance in asymmetric synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and advanced materials. This product is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for their synthetic workflows.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides, where the specific stereoisomer can significantly influence biological activity and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Flavor and Fragrance Industry: Employed in the research and production of chiral aroma chemicals, where the (R)-enantiomer can impart specific sensory characteristics.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and for studying structure-activity relationships (SAR) in medicinal chemistry programs.
• Material Science: Potential use as a monomer or building block for creating chiral polymers and liquid crystals with specialized optical properties.

Basic Information

Product Name	(R)-2-Phenyl-3-Methylbutanoic Acid
CAS No.	13491-13-9
Molecular Formula	C11H14O2
Molecular Weight	178.23 g/mol
Synonyms	(R)-2-Phenyl-3-methylbutyric acid; (R)-α-Phenyl-β-methylbutyric acid; (R)-3-Methyl-2-phenylbutanoic acid; D-2-Phenyl-3-methylbutanoic acid; (2R)-2-Phenyl-3-methylbutanoic acid; (R)-2-Phenyl-3-methylbutyric Acid; (R)-Hydrotropic acid derivative; (R)-α-Methylhydrocinnamic acid (related structure).
EINECS	Contact for details

Quality Control

Our production of (R)-2-Phenyl-3-Methylbutanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and titration for assay. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture. For long-term storage, consider using an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.