Description

(2S,3R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-{[(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-[(Triphenylmethyl)Carbamoyl]Propanoyl]Oxy}Butanoic Acid is a sophisticated, multi-protected amino acid derivative designed for advanced peptide synthesis. This compound matters as a critical building block for the controlled assembly of complex peptides and peptidomimetics, offering orthogonal protection strategies essential for research and pharmaceutical development. It is primarily needed by medicinal chemists, process R&D teams, and manufacturers in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of specific amino acids in automated peptide synthesizers.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methodologies for constructing peptide fragments.
• Pharmaceutical Research & Development: Serves as a crucial raw material in the discovery and development of peptide-based drugs, hormones, and diagnostic agents.
• Synthesis of Complex Peptidomimetics: Enables the incorporation of modified amino acid structures to enhance stability, bioavailability, or biological activity of target molecules.
• Bioconjugation and Labeling: The orthogonal protecting groups (Fmoc, Boc, Trt) allow for selective deprotection, facilitating site-specific modifications and labeling of peptides.
• Academic and Institutional Research: Used in university and institutional labs for studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	(2S,3R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-{[(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-[(Triphenylmethyl)Carbamoyl]Propanoyl]Oxy}Butanoic Acid
CAS No.	944283-34-5
Molecular Formula	C49H49N3O9
Molecular Weight	823.94 g/mol
Synonyms	Fmoc-Thr(OtBu)-OH (Trityl); Boc-Thr[Fmoc-Lys(Trt)-OH]-OH; N-α-Boc-O-[N-ε-Fmoc-N-α-(N'-Trityl)-L-lysyl]-L-threonine; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-[[(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-6-(triphenylmethylamino)-6-oxohexanoyl]oxy]butanoic acid; Fmoc-Lys(Trt)-Thr(OtBu)-OH; Boc-Thr(OtBu)-Lys(Fmoc, Trt)-OH; Protected Threonine-Lysine Dipeptide Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. We ensure compliance with current industry standards for research-grade and GMP-starting materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.