Description

7-Phenylacetamide-3-Hydroxy-3-Cephem-4-Carboxylic Acid p-Methoxybenzyl Ester is a key advanced pharmaceutical intermediate in the synthesis of cephalosporin antibiotics. This compound matters for its critical role as a protected precursor, enabling the efficient and controlled construction of the β-lactam core structure essential for antibiotic activity. It is primarily needed by fine chemical manufacturers and R&D laboratories engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research and development of novel β-lactam antibacterial agents.
• Fine Chemical Production: Serves as a high-value intermediate for contract manufacturing organizations (CMOs) specializing in complex organic molecules.
• Biochemical Research: Employed in academic and industrial research to study structure-activity relationships (SAR) in antibiotic design.
• Process Chemistry Development: Utilized for optimizing scalable synthetic routes for cephalosporin-class drugs.

Basic Information

Product Name	7-Phenylacetamide-3-Hydroxy-3-Cephem-4-Carboxylic Acid p-Methoxybenzyl Ester
CAS No.	123054-31-9
Molecular Formula	C26H24N2O6S
Molecular Weight	492.55 g/mol
Synonyms	(6R,7R)-7-[(2R)-2-Amino-2-phenylacetamido]-3-hydroxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester; 7-ADCA p-Methoxybenzyl Ester derivative; 3-Hydroxycephem PMB ester; 7-Phenylglycyl-3-hydroxycephem-4-PMB ester; 7-[(Phenylacetyl)amino]-3-hydroxy-3-cephem-4-carboxylic acid 4-methoxybenzyl ester; PMB-protected 3-hydroxycephem intermediate
EINECS	Contact for details

Quality Control

Our 7-Phenylacetamide-3-Hydroxy-3-Cephem-4-Carboxylic Acid p-Methoxybenzyl Ester is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.