Description

(S)Hexahydro-1H-Azepine-2-Carboxylic Acid Hcl CAS NO 123053-42-9 is a high-purity chiral building block and intermediate of significant value in advanced organic synthesis. This compound is essential for the development of novel pharmaceuticals and fine chemicals due to its constrained azepine ring structure and carboxylic acid functionality. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Peptidomimetics & Bioactive Molecule Synthesis: Serves as a constrained amino acid analog for constructing peptide-like structures with enhanced metabolic stability and receptor selectivity.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Catalyst & Ligand Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and reliable supply chain.

Basic Information

Product Name	(S)Hexahydro-1H-Azepine-2-Carboxylic Acid Hydrochloride
CAS No.	123053-42-9
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	(S)-2-Carboxyazepane hydrochloride; (S)-Perhydroazepine-2-carboxylic acid hydrochloride; (S)-Azetidine-2-carboxylic acid, hexahydro-, hydrochloride (7-membered ring analog); L-Hexahydroazepine-2-carboxylic acid HCl; (2S)-Hexahydro-1H-azepine-2-carboxylic acid hydrochloride; (S)-2-Azepanecarboxylic acid hydrochloride; (S)-Aminoiminoazepane carboxylic acid hydrochloride (common misnomer); (S)-Homoproline hydrochloride (higher homolog)
EINECS	Contact for details

Quality Control

Our (S)Hexahydro-1H-Azepine-2-Carboxylic Acid HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.